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Chemical structure of Exicorilant

GC70442

Exicorilant

Also known as [(4aR,8aS)-1-(4-fluorophenyl)-6-(2-methyltriazol-4-yl)sulfonyl-4,5,7,8,8a,9-hexahydropyrazolo[5,4-g]isoquinolin-4a-yl]-[4-(trifluoromethyl)-2-pyridinyl]methanone

Exicorilant (CORT 125281) is a selective and oral active glucocorticoid receptor (GR) antagonist, with a Ki value of 7 nM

ChemicalCAS1781244-77-6MW589.56FormulaC26H23F4N7O3S
CAS number
1781244-77-6
Molecular weight
589.56
Formula
C26H23F4N7O3S
Solubility
DMSO ： 250 mg/mL (424·05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
InChIKey
HWJYJKAURRIWJM-GKVSMKOHSA-N
Catalogue number
GC70442
Brand
GLPBIO
Computed properties PubChem CID 118092367 · XLogP 3.5 · TPSA 124 Ų · H-bond donors 0
XLogP
3.5
TPSA
124 Ų
H-bond donors
0
H-bond acceptors
12
Rotatable bonds
5
Heavy atoms
41

SMILES CN1N=CC(=N1)S(=O)(=O)N2CC[C@H]3CC4=C(C[C@@]3(C2)C(=O)C5=NC=CC(=C5)C(F)(F)F)C=NN4C6=CC=C(C=C6)F

Computed descriptors from PubChem (CID 118092367), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.