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Chemical structure of CM1

GB40149

CM1

Also known as N-[6-(3-hydroxy-2-methyl-4-oxo-1-pyridinyl)hexyl]acetamide

Orally active iron chelator with high af?nity and selectivity for iron(III) (relative metal complex stability constants of pFe(III)= 20·3; pCu(II)= 9·8; pZn(II)= 6·2) and a suit-able partition coef?cient to permeate membranes· CM1 is able to penetrate hepatocytes and relatively non toxic· Potential therapeutic for patients suffering from thalassaemia related iron overload Moreover, CM1 shows an inhibitory effect on the growth of Plasmodium falciparum (malaria parrasite; IC50 value 35 µM)

ChemicalCAS1643659-63-5MW266.34FormulaC14H22N2O3
CAS number
1643659-63-5
Molecular weight
266.34
Formula
C14H22N2O3
InChIKey
AUVGDBMRJYKPEA-UHFFFAOYSA-N
Catalogue number
GB40149
Brand
GLPBIO
Computed properties PubChem CID 117072346 · XLogP 1.2 · TPSA 69.6 Ų · H-bond donors 2
XLogP
1.2
TPSA
69.6 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
7
Heavy atoms
19

SMILES CC1=C(C(=O)C=CN1CCCCCCNC(=O)C)O

Computed descriptors from PubChem (CID 117072346), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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