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Chemical structure of CK2 inhibitor 10

GB40147

CK2 inhibitor 10

Also known as 4-[2-[(4-methoxybenzoyl)amino]-1,3-thiazol-5-yl]benzoic acid

Potent and ATP-competitive inhibitor of protein kinase (CK2; IC50 values of 32 nM and 46 nM for CK2α and CK2α' respectively)· At 0·30 μM, compound 10 exhibited a >50% inhibitory effect against 9 out of 70 other kinases besides CK2α and CK2α′, while at 30 nM >75% inhibition was observed for two other kinases (DYRK1B and FLT3) only· It exhibited potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116, and breast cancer cells MCF-7

ChemicalCAS1361229-76-6MW354.38FormulaC18H14N2O4S
CAS number
1361229-76-6
Molecular weight
354.38
Formula
C18H14N2O4S
InChIKey
UPIVZLFKYMNZDG-UHFFFAOYSA-N
Catalogue number
GB40147
Brand
GLPBIO
Computed properties PubChem CID 57342036 · XLogP 3.3 · TPSA 117 Ų · H-bond donors 2
XLogP
3.3
TPSA
117 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
25

SMILES COC1=CC=C(C=C1)C(=O)NC2=NC=C(S2)C3=CC=C(C=C3)C(=O)O

Computed descriptors from PubChem (CID 57342036), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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