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Chemical structure of AR 244555

GB40101

AR 244555

Also known as (1'-but-3-enyl-5-chlorospiro[2H-indole-3,4'-piperidine]-1-yl)-(2,6-difluorophenyl)methanone

Inverse agonist of Mas G-protein signaling (IC50 values 186 and 348 nM in human and rat inositol phosphatase (IP) Gq coupling assays respectively)· AR 244555 caused a dose-dependent inhibition of inositol 1,4,5-trisphosphate accumulation in AdMas-infected cells, and attenuated the sarcomeric organization and cell enlargement observed in Mas overexpressing myocytes·AR 244555 caused a modest but significant increase in coronary flow in rat hearts witout causing arrhythmias, and provides protection from ischemia-reperfusion injury if administered either before ischemia or immediately before reperfusion

ChemicalCAS858350-62-6MW416.89FormulaC23H23ClF2N2O
CAS number
858350-62-6
Molecular weight
416.89
Formula
C23H23ClF2N2O
InChIKey
QKPSTNGNDWHYCH-UHFFFAOYSA-N
Catalogue number
GB40101
Brand
GLPBIO
Computed properties PubChem CID 59004159 · XLogP 5.2 · TPSA 23.6 Ų · H-bond donors 0
XLogP
5.2
TPSA
23.6 Ų
H-bond donors
0
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
29

SMILES C=CCCN1CCC2(CC1)CN(C3=C2C=C(C=C3)Cl)C(=O)C4=C(C=CC=C4F)F

Computed descriptors from PubChem (CID 59004159), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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