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Chemical structure of APPA

GB40100

APPA

Also known as (1-acetyl-5-phenylpyrrol-3-yl) acetate

APPA is an aldose reductase inhibitor with an IC50 value of 0·0223 μM· APPA could inhibit apoptosis in rat glomerular mesangial cells in vitro· In addition, APPA improved the pathological symptoms of streptozotocin-induced diabetic nephropathy (DN) in rats by affecting antioxidant activities and reducing the levels of TGF-β, collagen IV, and laminin

ChemicalCAS100750-39-8MW243.26FormulaC14H13NO3
CAS number
100750-39-8
Molecular weight
243.26
Formula
C14H13NO3
InChIKey
WKSITCBIIIHVSF-UHFFFAOYSA-N
Catalogue number
GB40100
Brand
GLPBIO
Computed properties PubChem CID 13785326 · XLogP 2 · TPSA 48.3 Ų · H-bond donors 0
XLogP
2
TPSA
48.3 Ų
H-bond donors
0
H-bond acceptors
3
Rotatable bonds
3
Heavy atoms
18

SMILES CC(=O)N1C=C(C=C1C2=CC=CC=C2)OC(=O)C

Computed descriptors from PubChem (CID 13785326), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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