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Chemical structure of Z-Val-Ala-DL-Asp-fluoromethylketone

GA23963

Z-Val-Ala-DL-Asp-fluoromethylketone

Also known as 5-fluoro-3-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]propanoyl]amino]-4-oxopentanoic acid

zVAD-FMK inhibited apoptosis induced by diverse stimuli· Preincubation of cells with this caspase-1 (ICE) inhibitor (50 µM) almost completely inhibited the formation of large kilobase-pair fragments of DNA, a characteristic biochemical change associated with apoptosis·Z-VAD-FMK was shown to irreversibly inhibit most types of caspases, hence it is also called pan-caspase inhibitor· For a cell-permeable analog see N-1560·Inhibitor of peptide:N-glycanase (PNGase)

ChemicalCAS220644-02-0MW453.47FormulaC21H28FN3O7
CAS number
220644-02-0
Molecular weight
453.47
Formula
C21H28FN3O7
Solubility
Soluble in DMSO
InChIKey
SUUHZYLYARUNIA-LWSHRDBSSA-N
Catalogue number
GA23963
Brand
GLPBIO
Computed properties PubChem CID 5497170 · XLogP 1.6 · TPSA 151 Ų · H-bond donors 4
XLogP
1.6
TPSA
151 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
13
Heavy atoms
32

SMILES C[C@@H](C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)[C@H](C(C)C)NC(=O)OCC1=CC=CC=C1

Computed descriptors from PubChem (CID 5497170), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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