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Chemical structure of Z-Leu-Leu-Tyr-α-keto aldehyde

GA23855

Z-Leu-Leu-Tyr-α-keto aldehyde

Also known as benzyl N-[(2S)-1-[[(2S)-1-[[(2S)-1-(4-hydroxyphenyl)-3,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate

Z-LLY-α-keto aldehyde (peptidyl glyoxal), previously shown to be an excellent inhibitor of the serine and cysteine proteases, was found to be an excellent inhibitor of the chymotryptic-like activity of proteasome exhibiting a Ki value of approximately 3·0 nM· Such inhibitor might be valuable in the characterization of the role of proteasome in normal and aberrant pathways of protein catabolism in the cell

ChemicalCAS204649-66-1MW553.66FormulaC30H39N3O7
CAS number
204649-66-1
Molecular weight
553.66
Formula
C30H39N3O7
Solubility
Soluble in DMSO
InChIKey
HKFKZFVHAUUKCW-GSDHBNRESA-N
Catalogue number
GA23855
Brand
GLPBIO
Computed properties PubChem CID 10460295 · XLogP 3.7 · TPSA 151 Ų · H-bond donors 4
XLogP
3.7
TPSA
151 Ų
H-bond donors
4
H-bond acceptors
7
Rotatable bonds
16
Heavy atoms
40

SMILES CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC2=CC=CC=C2

Computed descriptors from PubChem (CID 10460295), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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