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Chemical structure of Thrombin Receptor Antagonist

GA23607

Thrombin Receptor Antagonist

Also known as (2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-1-[(2R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-sulfanylpropanoyl]pyrrolidine-2-carbonyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]pentanedioic acid

The peptide T1, MSRPACPNDKYE, is based on the sequence of the thrombin receptor domain that functions as a tethered ligand for the receptor itself· T1 has been selected from a phage peptide library as an inhibitor of thrombin triggered platelet aggregation, serotonin release and tyrosine phosphorylation· Its anti-aggregatory activity was about ten-fold higher than that of the previously reported peptide antagonists of the thrombin receptor·MSRPACPNDKYE has served as model peptide in protein modification and MS studies

ChemicalCAS207553-92-2MW1410.6FormulaC58H91N17O20S2
CAS number
207553-92-2
Molecular weight
1410.6
Formula
C58H91N17O20S2
Solubility
Soluble in DMSO
InChIKey
CSEYOQGUZFFDDP-CALNTKBMSA-N
Catalogue number
GA23607
Brand
GLPBIO
Computed properties PubChem CID 24868226 · XLogP -11 · TPSA 641 Ų · H-bond donors 20
XLogP
-11
TPSA
641 Ų
H-bond donors
20
H-bond acceptors
25
Rotatable bonds
43
Heavy atoms
97

SMILES C[C@@H](C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)N

Computed descriptors from PubChem (CID 24868226), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.