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Chemical structure of TGF α (34-43) (rat)

GA23606

TGF α (34-43) (rat)

Also known as 31-amino-7-[3-(diaminomethylideneamino)propyl]-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-5-ylmethyl)-6,9,12,15,18,21,24,27,30-nonaoxo-10,16-di(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carboxylic acid

The fragment CHSGYVGVRC comprises the third disulfide loop of rat TGF α· Antibodies elicited against the synthetic decapeptide crossreacted with native TGF α but not EGF· The peptide competed with EGF for binding to its receptors and was found to be an antagonist of EGF-induced mitogenesis· More recent results indicate that administration of TGF α (34-43) inhibits the development of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine

ChemicalCAS97474-88-9MW1078.24FormulaC44H67N15O13S2
CAS number
97474-88-9
Molecular weight
1078.24
Formula
C44H67N15O13S2
Solubility
Soluble in DMSO
InChIKey
MIHUXUMZEJHQNC-UHFFFAOYSA-N
Catalogue number
GA23606
Brand
GLPBIO
Computed properties PubChem CID 4054112 · XLogP -5.1 · TPSA 509 Ų · H-bond donors 16
XLogP
-5.1
TPSA
509 Ų
H-bond donors
16
H-bond acceptors
18
Rotatable bonds
12
Heavy atoms
74

SMILES CC(C)C1C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)NCC(=O)N1)C(C)C)CC2=CC=C(C=C2)O)CO)CC3=CN=CN3)N)C(=O)O)CCCN=C(N)N

Computed descriptors from PubChem (CID 4054112), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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