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Chemical structure of Suc-Ala-Ala-Pro-Phe-AMC

GA23535

Suc-Ala-Ala-Pro-Phe-AMC

Also known as 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-2-[(4-methyl-2-oxochromen-7-yl)amino]-3-phenylpropanoyl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

The peptidylprolyl isomerase substrate Suc-AAPF-AMC is also hydrolyzed by carboxypeptidase Y, cathepsin G, and chymotrypsin· Suc-AAPF-AMC has also been used to analyze the chymotrypsin-like activity of trypsins

ChemicalCAS88467-45-2MW661.71FormulaC34H39N5O9
CAS number
88467-45-2
Molecular weight
661.71
Formula
C34H39N5O9
Solubility
DMSO ： 100 mg/mL (151·13 mM; Need ultrasonic)
InChIKey
IGKPQFYMWKQDQS-KCXKOMAXSA-N
Catalogue number
GA23535
Brand
GLPBIO
Computed properties PubChem CID 5487862 · XLogP 1.9 · TPSA 200 Ų · H-bond donors 5
XLogP
1.9
TPSA
200 Ų
H-bond donors
5
H-bond acceptors
10
Rotatable bonds
13
Heavy atoms
48

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)N[C@@H](CC3=CC=CC=C3)C(=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)O

Computed descriptors from PubChem (CID 5487862), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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