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Chemical structure of Suc-Ala-Ala-Phe-AMC

GA23524

Suc-Ala-Ala-Phe-AMC

Also known as 4-[[1-[[1-[[1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

Suc-AAF-AMC, a highly sensitive fluorogenic chymotrypsin substrate· It is also hydrolyzed by neutral metalloendopeptidases, such as thermolysin and enkephalinase (neprilysin, NEP 24·11)· Suc-AAF-MCA has also been used for the chymotrypsin-like activity of the 20S proteasome

ChemicalCAS71973-79-0MW564.6FormulaC29H32N4O8
CAS number
71973-79-0
Molecular weight
564.6
Formula
C29H32N4O8
Solubility
DMSO : 250 mg/mL (442·80 mM; ultrasonic and warming and heat to 60°C)
InChIKey
HHPVJKZZYOXPLH-UHFFFAOYSA-N
Catalogue number
GA23524
Brand
GLPBIO
Computed properties PubChem CID 3265780 · XLogP 1.3 · TPSA 180 Ų · H-bond donors 5
XLogP
1.3
TPSA
180 Ų
H-bond donors
5
H-bond acceptors
8
Rotatable bonds
12
Heavy atoms
41

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)O

Computed descriptors from PubChem (CID 3265780), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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