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Chemical structure of Pyr-Pro-Arg-pNA

GA23430

Pyr-Pro-Arg-pNA

Also known as (2S)-N-[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]-1-[(2S)-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide

The chromogenic substrate pEPR-pNA has been used for the determination of kinetic constants of tryptase (EC 3·4·21·59) from guinea pig (Km = 0·24 - 0·26 mM) and human (Km = 0·24 - 0·43 mM)· Pyr-Pro-Arg-pNA has also been used as substrate for the coagulation factor XIa· Km and kcat values for this substrate were 0·56 mM and 350 s?¹, respectively

ChemicalCAS72194-57-1MW502.53FormulaC22H30N8O6
CAS number
72194-57-1
Molecular weight
502.53
Formula
C22H30N8O6
Solubility
Soluble in DMSO
InChIKey
WPVINHLVHHPBMK-ULQDDVLXSA-N
Catalogue number
GA23430
Brand
GLPBIO
Computed properties PubChem CID 126364 · XLogP -1 · TPSA 218 Ų · H-bond donors 5
XLogP
-1
TPSA
218 Ų
H-bond donors
5
H-bond acceptors
7
Rotatable bonds
9
Heavy atoms
36

SMILES C1C[C@H](N(C1)C(=O)[C@@H]2CCC(=O)N2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NC3=CC=C(C=C3)[N+](=O)[O-]

Computed descriptors from PubChem (CID 126364), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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