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Chemical structure of Pyr-Arg-Thr-Lys-Arg-AMC

GA23423

Pyr-Arg-Thr-Lys-Arg-AMC

Also known as (2S)-N-[(2S)-1-[[(2S,3R)-1-[[(2S)-6-amino-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-5-oxopyrrolidine-2-carboxamide

The fluorogenic substrate pERTKR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx· 2·10? M-¹s-¹)· As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues· Also cleaved by proprotein convertase 4·Pyr-RTKR-AMC is an excellent substrate for flavivirin

ChemicalCAS155575-02-3MW827.94FormulaC37H57N13O9
CAS number
155575-02-3
Molecular weight
827.94
Formula
C37H57N13O9
Solubility
Soluble in DMSO
InChIKey
ZJRJBAKJWMHKFK-URVADDRRSA-N
Catalogue number
GA23423
Brand
GLPBIO
Computed properties PubChem CID 71311916 · XLogP -3.8 · TPSA 376 Ų · H-bond donors 12
XLogP
-3.8
TPSA
376 Ų
H-bond donors
12
H-bond acceptors
12
Rotatable bonds
23
Heavy atoms
59

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]3CCC(=O)N3

Computed descriptors from PubChem (CID 71311916), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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