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Chemical structure of Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH₂

GA23181

Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH₂

Also known as (4S)-5-[[(2S)-1-[[(2S)-1-amino-3-(2,4-dinitroanilino)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-[[(2S)-4-carboxy-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[2-(7-methoxy-2-oxochromen-4-yl)acetyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]butanoyl]amino]-5-oxopentanoic acid

Highly selective MMP-12 FRET substrate with a kcat/Km value of 1·85 · 10⁵ M⁻¹s⁻¹· Poor substrate of other MMPs with the exception of MMP-13 (kcat/Km = 0·53 · 10 ⁵ M⁻¹s⁻¹) and MMP-9 (0·33 · 10⁵ M⁻¹s⁻¹)

ChemicalCAS891198-38-2MW1195.21FormulaC53H70N12O20
CAS number
891198-38-2
Molecular weight
1195.21
Formula
C53H70N12O20
Solubility
Soluble in DMSO
InChIKey
IUIVVOHCYZAJIV-PFQABZGHSA-N
Catalogue number
GA23181
Brand
GLPBIO
Computed properties PubChem CID 131863087 · XLogP 1.3 · TPSA 481 Ų · H-bond donors 11
XLogP
1.3
TPSA
481 Ų
H-bond donors
11
H-bond acceptors
21
Rotatable bonds
31
Heavy atoms
85

SMILES C[C@@H](C(=O)N[C@@H](CNC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-])C(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)CC3=CC(=O)OC4=C3C=CC(=C4)OC

Computed descriptors from PubChem (CID 131863087), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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