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Chemical structure of Mca-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH₂

GA23178

Mca-Gly-Ser-Pro-Ala-Phe-Leu-Ala-Lys(Dnp)-D-Arg-NH₂

Also known as (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-6-(2,4-dinitroanilino)-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxopropan-2-yl]-1-[(2S)-3-hydroxy-2-[[2-[[2-(7-methoxy-2-oxochromen-4-yl)acetyl]amino]acetyl]amino]propanoyl]pyrrolidine-2-carboxamide

Highly sensitive and selective cathepsin E FRET substrate derived from the cleavage site sequence of human α2-macroglobulin (Km = 1·9 µM; kcat/Km = 10·2 µM?¹s?¹ for human erythrocyte cathepsin E)· The substrate was resistent to hydrolysis by the analogous aspartic proteinases cathepsin D and pepsin, as well as the lysosomal cysteine proteinases cathepsin B, L, and H· Useful for monitoring and accurately quantifying cathepsin E, even in crude enzyme preparations (excitation wavelength at 328 nm, emission wavelength at 393 nm)

ChemicalCAS592544-81-5MW1327.42FormulaC61H82N16O18
CAS number
592544-81-5
Molecular weight
1327.42
Formula
C61H82N16O18
Solubility
Soluble in DMSO
InChIKey
NSIRVLHIYQWTDO-BRHSRUOZSA-N
Catalogue number
GA23178
Brand
GLPBIO
Computed properties PubChem CID 91869628 · XLogP 1.1 · TPSA 520 Ų · H-bond donors 13
XLogP
1.1
TPSA
520 Ų
H-bond donors
13
H-bond acceptors
20
Rotatable bonds
35
Heavy atoms
95

SMILES C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-])C(=O)N[C@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CO)NC(=O)CNC(=O)CC4=CC(=O)OC5=C4C=CC(=C5)OC

Computed descriptors from PubChem (CID 91869628), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.