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Chemical structure of Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)

GA23173

Mca-(endo-1a-Dap(Dnp))-TNF-α (-5 to +6) amide (human)

Also known as (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(2,4-dinitroanilino)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[2-(7-methoxy-2-oxochromen-4-yl)acetyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]pentanediamide

Mca-PLAQAV-Dpa-RSSSR-amide, a fluorogenic (FRET) peptide substrate for tumor necrosis factor (TNF) converting enzyme (TACE, ADAM-17 endopeptidase)

ChemicalCAS192723-42-5MW1638.72FormulaC69H103N23O24
CAS number
192723-42-5
Molecular weight
1638.72
Formula
C69H103N23O24
Solubility
Soluble in DMSO
InChIKey
QWPFCDHLHMOCKZ-ZZLDSPSDSA-N
Catalogue number
GA23173
Brand
GLPBIO
Computed properties PubChem CID 135921883 · XLogP -5.4 · TPSA 755 Ų · H-bond donors 21
XLogP
-5.4
TPSA
755 Ų
H-bond donors
21
H-bond acceptors
27
Rotatable bonds
46
Heavy atoms
116

SMILES C[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CNC1=C(C=C(C=C1)[N+](=O)[O-])[N+](=O)[O-])C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)CC3=CC(=O)OC4=C3C=CC(=C4)OC

Computed descriptors from PubChem (CID 135921883), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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