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Chemical structure of Galanin (1-13)-Spantide I

GA21888

Galanin (1-13)-Spantide I

Also known as (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-[[(2S)-1-[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2R)-1-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide

Galanin receptor antagonist which inhibits galanin-induced feeding in rats· C7 displaced binding of (¹²?I-Tyr²?)-galanin (porcine) in rat hypothalamic membranes with an IC?? value of 0·2 nM, as compared to IC?? values of 150 nM and 0·8 nM for galanin (1-13) and galanin (1-29) (porcine), respectively

ChemicalCAS143868-20-6MW2828.32FormulaC138H199N35O30
CAS number
143868-20-6
Molecular weight
2828.32
Formula
C138H199N35O30
Solubility
Soluble in DMSO
InChIKey
OETYBDQHOHLNBH-GNXGYILWSA-N
Catalogue number
GA21888
Brand
GLPBIO
Computed properties PubChem CID 16132250 · XLogP 0.5 · TPSA 1040 Ų · H-bond donors 35
XLogP
0.5
TPSA
1040 Ų
H-bond donors
35
H-bond acceptors
34
Rotatable bonds
82
Heavy atoms
203

SMILES C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(=N)N)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](CC5=CNC6=CC=CC=C65)C(=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC7=CNC8=CC=CC=C87)NC(=O)[C@H](CC9=CC=CC=C9)N)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)CN)O

Computed descriptors from PubChem (CID 16132250), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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