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Chemical structure of Galanin-Like Peptide (rat)

GA21892

Galanin-Like Peptide (rat)

Galanin-like peptide (GALP), first isolated from the porcine hypothalamus and subsequently also identified in rats and humans, is a 60 amino acid neuropeptide that unlike galanin, has a non-amidated C-terminus· Its amino acid residues (9-21) are identical to the biologically active N-terminal (1-13) fragment of galanin· In contrast to galanin which is relatively non-selective, receptor binding studies revealed that GALP had a high affinity for the galanin receptor 2 (GALR2) and a lower affinity for the GALR1 receptor· Furthermore, it could be demonstrated that GALP stimulates food intake with a ten fold higher orexigenic activity than galanin and may also affect emotional state in the CNS

ChemicalCAS245114-97-0MW6502.43FormulaC288H461N87O83S
CAS number
245114-97-0
Molecular weight
6502.43
Formula
C288H461N87O83S
Solubility
Soluble in DMSO
Catalogue number
GA21892
Brand
GLPBIO

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