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Chemical structure of DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH₂

GA21361

DABCYL-γ-Abu-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH₂

Also known as 5-[2-[[4-[[2-[[2-[[5-amino-2-[[1-[4-[[4-[[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]butanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-[[1-[(1,6-diamino-1-oxohexan-2-yl)amino]-1-oxopropan-2-yl]amino]-5-oxopentanoyl]amino]ethylamino]naphthalene-1-sulfonic acid

Highly soluble fluorogenic (FRET) matrix metalloproteinase (MMP) substrate with the following kcat/Km values (at pH 7·6, 37 °C): 619·000 M⁻¹s⁻¹ for MMP-2, 209·000 M⁻¹s⁻¹ for MMP-9, 40·000 M⁻¹s⁻¹ for MMP-3, and 21·000 M⁻¹s⁻¹ for MMP-1· The fluorescence increase is measured using an excitation wavelength of 340 nm and an emission wavelength of 485 nm· Due to the relatively high emission wavelength of EDANS the substrate allows convenient measurement of MMP activity in complex biological media like synovial fluid and culture medium

ChemicalCAS193475-71-7MW1325.56FormulaC63H88N16O14S
CAS number
193475-71-7
Molecular weight
1325.56
Formula
C63H88N16O14S
Solubility
Soluble in DMSO
InChIKey
SRCLUDHDMWVELQ-UHFFFAOYSA-N
Catalogue number
GA21361
Brand
GLPBIO
Computed properties PubChem CID 165365382 · XLogP -1 · TPSA 468 Ų · H-bond donors 13
XLogP
-1
TPSA
468 Ų
H-bond donors
13
H-bond acceptors
19
Rotatable bonds
38
Heavy atoms
94

SMILES CC(C)CC(C(=O)NC(CCC(=O)NCCNC1=CC=CC2=C1C=CC=C2S(=O)(=O)O)C(=O)NC(C)C(=O)NC(CCCCN)C(=O)N)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)CCCNC(=O)C4=CC=C(C=C4)N=NC5=CC=C(C=C5)N(C)C

Computed descriptors from PubChem (CID 165365382), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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