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Chemical structure of Boc-Val-Pro-Arg-AMC

GA21166

Boc-Val-Pro-Arg-AMC

Also known as tert-butyl N-[(2S)-1-[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[(4-methyl-2-oxochromen-7-yl)amino]pentanoyl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate

Boc-VPR-AMC, a specific, highly fluorogenic substrate for thrombin and the thrombin-staphylocoagulase complex· The thrombin assay has been used for the indirect determination of coagulation factor III· Trypsin, tryptase from rat mast cells, and two trypsin-like enzymes from sperm of the ascidian Halocynthia roretzi, acrosin and spermosin, also hydrolyze this substrate· Furthermore, Boc-VPR-AMC is cleaved by the Kex2 endoprotease (kexin, previously known as proteinase yscF), a membrane-bound, calcium-dependent serine protease from yeast α-cells· Kinetic data for Thrombin: kcat = 105, Km = 21 uM

ChemicalCAS65147-04-8MW627.74FormulaC31H45N7O7
CAS number
65147-04-8
Molecular weight
627.74
Formula
C31H45N7O7
Solubility
Soluble in DMSO
InChIKey
JEOIUGLPMJAHBL-HWBMXIPRSA-N
Catalogue number
GA21166
Brand
GLPBIO
Computed properties PubChem CID 125185 · XLogP 2.3 · TPSA 208 Ų · H-bond donors 5
XLogP
2.3
TPSA
208 Ų
H-bond donors
5
H-bond acceptors
9
Rotatable bonds
13
Heavy atoms
45

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)N[C@@H](CCCN=C(N)N)C(=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C(C)C)NC(=O)OC(C)(C)C

Computed descriptors from PubChem (CID 125185), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.