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Chemical structure of Boc-Arg-Val-Arg-Arg-AMC

GA20901

Boc-Arg-Val-Arg-Arg-AMC

Also known as tert-butyl N-[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopentan-2-yl]carbamate

The fluorogenic substrate Boc-RVRR-AMC is efficiently cleaved by furin, a mammalian homolog of the yeast Kex2 endoprotease (kcat/Km approx· 4·10³ M?¹s?¹)· As a calcium-dependent serine protease associated with Golgi membranes, furin is responsible for the secretory processing of precursor proteins at paired basic residues· Boc-RVRR-AMC is also cleaved by proprotein convertase 4·Stock solutions of Boc-RVRR-AMC are best prepared in DMSO

ChemicalCAS136132-77-9MW843.01FormulaC38H62N14O8
CAS number
136132-77-9
Molecular weight
843.01
Formula
C38H62N14O8
Solubility
H2O ： 100 mg/mL (113·71 mM; Need ultrasonic)
InChIKey
YWISVGSSAYEYKH-VZTVMPNDSA-N
Catalogue number
GA20901
Brand
GLPBIO
Computed properties PubChem CID 88062448 · XLogP -1.3 · TPSA 374 Ų · H-bond donors 11
XLogP
-1.3
TPSA
374 Ų
H-bond donors
11
H-bond acceptors
11
Rotatable bonds
24
Heavy atoms
60

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)OC(C)(C)C

Computed descriptors from PubChem (CID 88062448), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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