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Chemical structure of Ac-Tyr-Val-Ala-Asp-AMC

GA20673

Ac-Tyr-Val-Ala-Asp-AMC

Also known as 3-[2-[[2-[[2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylbutanoyl]amino]propanoylamino]-4-[(4-methyl-2-oxochromen-7-yl)amino]-4-oxobutanoic acid

Ac-YVAD-AMC is a fluorogenic substrate for caspase-1 (ICE)· It displayed a Km of 8·5 ± 0·5 µM for recombinant human caspase-1

ChemicalCAS149231-65-2MW665.7FormulaC33H39N5O10
CAS number
149231-65-2
Molecular weight
665.7
Formula
C33H39N5O10
Solubility
Soluble in DMSO
InChIKey
YGLOALWHJIANIH-UHFFFAOYSA-N
Catalogue number
GA20673
Brand
GLPBIO
Computed properties PubChem CID 4337 · XLogP 1.3 · TPSA 229 Ų · H-bond donors 7
XLogP
1.3
TPSA
229 Ų
H-bond donors
7
H-bond acceptors
10
Rotatable bonds
14
Heavy atoms
48

SMILES CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC3=CC=C(C=C3)O)NC(=O)C

Computed descriptors from PubChem (CID 4337), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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