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Chemical structure of Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

GA20660

Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)

Also known as (4S)-4-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-carboxy-3-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Ac-WEHD-CHO, a very potent reversible inhibitor of caspase-1 (ICE)· It bears the optimal tetrapeptide recognition motif for this enzyme· With a Ki of 56 pM it belongs to the most potent reversible, peptide-based inhibitors described for any protease· For caspase-8 a Ki of 21·1 nM has been reported

ChemicalCAS189275-71-6MW611.61FormulaC28H33N7O9
CAS number
189275-71-6
Molecular weight
611.61
Formula
C28H33N7O9
Solubility
Soluble in DMSO
InChIKey
ZSZYUXBVDPGGGX-QGQQZZQASA-N
Catalogue number
GA20660
Brand
GLPBIO
Computed properties PubChem CID 5311140 · XLogP -1.2 · TPSA 253 Ų · H-bond donors 8
XLogP
-1.2
TPSA
253 Ų
H-bond donors
8
H-bond acceptors
10
Rotatable bonds
17
Heavy atoms
44

SMILES CC(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](CC(=O)O)C=O

Computed descriptors from PubChem (CID 5311140), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.