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Chemical structure of Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid)

GA20493

Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid)

Also known as (4S)-4-[[(2S)-2-acetamido-3-carboxypropanoyl]amino]-5-[[(2S)-1-[[(2S)-1-carboxy-3-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid

Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC?? = 0·2 nM)· PARP cleavage occurs at the onset of apoptosis· The peptide aldehyde was able to attenuate apoptotic events in vitro (IC?? = 10 to 100 nM)

ChemicalCAS184179-08-6MW502.48FormulaC20H30N4O11
CAS number
184179-08-6
Molecular weight
502.48
Formula
C20H30N4O11
Solubility
Soluble in DMSO
InChIKey
UMBVAPCONCILTL-MRHIQRDNSA-N
Catalogue number
GA20493
Brand
GLPBIO
Computed properties PubChem CID 644345 · XLogP -2.6 · TPSA 245 Ų · H-bond donors 7
XLogP
-2.6
TPSA
245 Ų
H-bond donors
7
H-bond acceptors
11
Rotatable bonds
16
Heavy atoms
35

SMILES CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)C

Computed descriptors from PubChem (CID 644345), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Lead time
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