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Chemical structure of (D-Arg¹,D-Trp⁵,⁷,⁹,Leu¹¹)-Substance P

GA20074

(D-Arg¹,D-Trp⁵,⁷,⁹,Leu¹¹)-Substance P

Also known as (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide

This substance P analog is a very potent broad-spectrum neuropeptide inhibitor for small cell lung cancer (SCLC) cell growth in vitro (IC?? = 5 µM)· Moreover it potently inhibited signal transduction pathways in vitro and significantly delayed the growth of an SCLC xenograft in vivo· It could therefore be of therapeutic value in SCLC

ChemicalCAS122481-75-8MW1555.89FormulaC81H110N20O12
CAS number
122481-75-8
Molecular weight
1555.89
Formula
C81H110N20O12
Solubility
Soluble in DMSO
InChIKey
QDZOEBFLNHCSSF-PFFBOGFISA-N
Catalogue number
GA20074
Brand
GLPBIO
Computed properties PubChem CID 16138252 · XLogP 3.9 · TPSA 521 Ų · H-bond donors 18
XLogP
3.9
TPSA
521 Ų
H-bond donors
18
H-bond acceptors
15
Rotatable bonds
43
Heavy atoms
113

SMILES CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](CC6=CNC7=CC=CC=C76)NC(=O)[C@@H]8CCCN8C(=O)[C@H](CCCCN)NC(=O)[C@@H]9CCCN9C(=O)[C@@H](CCCNC(=N)N)N

Computed descriptors from PubChem (CID 16138252), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.