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Chemical structure of Substance P, phe(5)-trp(7,9)-leu(11)-

GA20072

Substance P, phe(5)-trp(7,9)-leu(11)-

Also listed as (D-Arg¹,D-Phe⁵,D-Trp⁷,⁹,Leu¹¹)-Substance P

(D-Arg¹,D-Phe?,D-Trp?·?,Leu¹¹)-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC?? = 5·2 nM)· In COS-7 cells transiently transfected with the ghrelin receptor the substance P analog rPKPfQwFwLL decreased the constitutive signaling down to levels observed in untransfected cells· Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control, inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity· So, Asakawa et al· found that peripherally administered H-6395 decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice

ChemicalCAS96736-12-8MW1516.86FormulaC79H109N19O12
CAS number
96736-12-8
Molecular weight
1516.86
Formula
C79H109N19O12
Solubility
Soluble in DMSO
InChIKey
XVOCEQLNJQGCQG-UNAVROQCSA-N
Catalogue number
GA20072
Brand
GLPBIO
Computed properties PubChem CID 25077998 · XLogP 3.4 · TPSA 508 Ų · H-bond donors 16
XLogP
3.4
TPSA
508 Ų
H-bond donors
16
H-bond acceptors
15
Rotatable bonds
42
Heavy atoms
110

SMILES CC(C)C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC2=CC=CC=C21)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CNC5=CC=CC=C54)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC6=CC=CC=C6)NC(=O)[C@@H]7CCCN7C(=O)[C@H](CCCCN)NC(=O)[C@@H]8CCCN8C(=O)[C@H](CCCN=C(N)N)N

Computed descriptors from PubChem (CID 25077998), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.