Conjugated TrkB Rabbit mAb

Target background

Target: BDNF/NT-3 growth factors receptor (Ntrk2) · Mus musculus

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation.

Subcellular location: Cell membrane; Endosome membrane; Early endosome membrane; Cell projection, axon; Cell projection, dendrite; Cytoplasm, perinuclear region; Postsynaptic density

Tissue specificity: Expressed in the brain, in neurons (at protein level). Detected in hippocampus (at protein level). Widely expressed in the central and peripheral nervous system. The different forms are differentially expressed in various cell types. Isoform GP95-TRKB is specifically expressed in glial cells

Sequence length: 821 aa · 92133 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.