Conjugated TrkB(Phospho-Y817) Rabbit mAb

Target background

Target: BDNF/NT-3 growth factors receptor (NTRK2) · Homo sapiens

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation.

Subcellular location: Cell membrane; Endosome membrane; Early endosome membrane; Cell projection, axon; Cell projection, dendrite; Cytoplasm, perinuclear region; Postsynaptic density

Tissue specificity: Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord.

Sequence length: 822 aa · 91999 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.