59398
ADAM10 Rabbit mAb
ADAM10 Rabbit mAb (catalogue number 59398) is a recombinant rabbit-derived primary antibody validated for WB IP, reactive with Human Mouse Rat samples. It targets Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10): Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Supplied in 2 pack sizes, from 50ul at ₪1,015.65 to 100ul at ₪1,382.75; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.
- Host / source
- Recombinant Rabbit
- Reactivity
- Human Mouse Rat
- Applications
- WB IP
- UniProt ID
- O14672
- Gene
- ADAM10
- Target organism
- Homo sapiens
- Catalogue number
- 59398
- Brand
- LABO Scientific
- Storage
- Store at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.
Target background
Target: Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) · Homo sapiens
Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins, including adhesion proteins, growth factor precursors and cytokines being essential for development and tissue homeostasis. Associates with six members of the tetraspanin superfamily TspanC8 which regulate its exit from the endoplasmic reticulum and its substrate selectivity. Cleaves the membrane-bound precursor of TNF at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface.
Subcellular location: Cell membrane; Golgi apparatus membrane; Cytoplasmic vesicle, clathrin-coated vesicle; Cell projection, axon; Cell projection, dendrite; Cell junction, adherens junction; Cytoplasm
Tissue specificity: Expressed in the brain (at protein level). Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver
Sequence length: 748 aa · 84142 Da
Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Storage
- Store at +4˚C short term. Store at -20˚C long term. Avoid freeze / thaw cycle.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il