CFTR (Phospho-Ser737) Antibody

Target background

Target: Cystic fibrosis transmembrane conductance regulator (CFTR) · Homo sapiens

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. In vitro, mediates ATP-dependent glutathione flux.

Subcellular location: Apical cell membrane; Early endosome membrane; Cell membrane; Recycling endosome membrane; Endoplasmic reticulum membrane; Nucleus

Tissue specificity: Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level). Detected in pancreatic intercalated ducts in the exocrine tissue, on epithelial cells in intralobular striated ducts in sublingual salivary glands, on apic…

Sequence length: 1480 aa · 168142 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.