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Rb (Acetyl-K873/K874) Polyclonal Antibody

HW189

Rb (Acetyl-K873/K874) Polyclonal Antibody

Rb (Acetyl-K873/K874) Polyclonal Antibody (catalogue number HW189) is a rabbit-derived primary antibody validated for Western blot, reactive with Hu Ms Rt samples. It targets Retinoblastoma-associated protein (RB1): Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. Supplied in 2 pack sizes, from 50ul at ₪893.28 to 100ul at ₪1,301.17; the final price is confirmed on your quote and the lot certificate of analysis ships with the order.

Primary AntibodyHostRabbit
Host / source
Rabbit
Reactivity
Hu Ms Rt
Applications
Western blot
UniProt ID
P06400
Gene
RB1
Target organism
Homo sapiens
Catalogue number
HW189
Brand
LABO Scientific
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target background

Target: Retinoblastoma-associated protein (RB1) · Homo sapiens

Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase.

Subcellular location: Nucleus; Cytoplasm

Tissue specificity: Expressed in the retina. Expressed in foreskin keratinocytes (at protein level)

Sequence length: 928 aa · 106159 Da

Protein background from UniProtKB, licensed under CC BY 4.0. Describes the target antigen, not this product.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Storage
Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.