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Chemical structure of Homer

GC92082

Homer

Also known as N-[5-[4-[[5-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-5-oxopentyl]carbamoyl]phenyl]-2-(4-methylpiperazin-1-yl)phenyl]-6-oxo-4-(trifluoromethyl)-1H-pyridine-3-carboxamide

Homer is a proteolysis-targeting chimera (PROTAC) composed of the probe for WD repeat domain 5 (WDR5) OICR-9429 and a von Hippel-Lindau (VHL) ligand

ChemicalCAS2737222-94-3MW1012.2FormulaC52H60F3N9O7S
CAS number
2737222-94-3
Molecular weight
1012.2
Formula
C52H60F3N9O7S
Solubility
Acetonitrile： Slightly Soluble： 0·1–1 mg/mL,DMSO： Sparingly Soluble： 1–10 mg/mL,Methanol： Slightly Soluble： 0·1–1 mg/mL
InChIKey
OFNZESNEBSQKSE-BQGOKDIQSA-N
Catalogue number
GC92082
Brand
GLPBIO
Computed properties PubChem CID 157049306 · XLogP 4.8 · TPSA 234 Ų · H-bond donors 6
XLogP
4.8
TPSA
234 Ų
H-bond donors
6
H-bond acceptors
14
Rotatable bonds
17
Heavy atoms
72

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCNC(=O)C4=CC=C(C=C4)C5=CC(=C(C=C5)N6CCN(CC6)C)NC(=O)C7=CNC(=O)C=C7C(F)(F)F)O

Computed descriptors from PubChem (CID 157049306), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.