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Chemical structure of Tanimilast

GC75881

Tanimilast

Also known as [(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] 3-(cyclopropylmethoxy)-4-(methanesulfonamido)benzoate

Tanimilast (CHF-6001) is a novel highly potent and selective phosphodiesterase 4 inhibitor(IC50=0·026 ± 0·006 nM) with robust anti-inflammatory activity and suitable for topical pulmonary administration

ChemicalCAS1239278-59-1MW687.54FormulaC30H30Cl2F2N2O8S
CAS number
1239278-59-1
Molecular weight
687.54
Formula
C30H30Cl2F2N2O8S
Solubility
DMSO： 200 mg/mL (290·89 mM; Need ultrasonic and warming)
InChIKey
VCFBPAOSTLMYIV-SANMLTNESA-N
Catalogue number
GC75881
Brand
GLPBIO
Computed properties PubChem CID 70662473 · XLogP 5.8 · TPSA 134 Ų · H-bond donors 1
XLogP
5.8
TPSA
134 Ų
H-bond donors
1
H-bond acceptors
11
Rotatable bonds
16
Heavy atoms
45

SMILES CS(=O)(=O)NC1=C(C=C(C=C1)C(=O)O[C@@H](CC2=C(C=[N+](C=C2Cl)[O-])Cl)C3=CC(=C(C=C3)OC(F)F)OCC4CC4)OCC5CC5

Computed descriptors from PubChem (CID 70662473), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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