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Chemical structure of RO-275

GC75708

RO-275

Also known as 4-[2-(2-chloro-3-methyl-4-pyridinyl)ethynyl]-5-methyl-1-pyridin-3-ylimidazole-2-carboxamide

RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0·046, 14·3, 4·6, 13·9 ?M for HCN1, HCN2, HCN3, HCN4, respectively

ChemicalCAS2648837-04-9MW351.79FormulaC18H14ClN5O
CAS number
2648837-04-9
Molecular weight
351.79
Formula
C18H14ClN5O
Solubility
DMSO： 5 mg/mL (14·21 mM; ultrasonic and warming and heat to 60°C)
InChIKey
STQKUEFQEVDNLU-UHFFFAOYSA-N
Catalogue number
GC75708
Brand
GLPBIO
Computed properties PubChem CID 156441547 · XLogP 2.5 · TPSA 86.7 Ų · H-bond donors 1
XLogP
2.5
TPSA
86.7 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
4
Heavy atoms
25

SMILES CC1=C(C=CN=C1Cl)C#CC2=C(N(C(=N2)C(=O)N)C3=CN=CC=C3)C

Computed descriptors from PubChem (CID 156441547), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.