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Chemical structure of Spiclomazine

GC75548

Spiclomazine

Also known as 8-[3-(2-chlorophenothiazin-10-yl)propyl]-1-thia-4,8-diazaspiro[4.5]decan-3-one

Spiclomazine (Clospirazine) is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer

ChemicalCAS24527-27-3MW446.03FormulaC22H24ClN3OS2
CAS number
24527-27-3
Molecular weight
446.03
Formula
C22H24ClN3OS2
Solubility
DMSO： 125 mg/mL (280·25 mM; ultrasonic and warming and heat to 60°C)
InChIKey
CFOYBMUYCBSDAL-UHFFFAOYSA-N
Catalogue number
GC75548
Brand
GLPBIO
Computed properties PubChem CID 65714 · XLogP 5.3 · TPSA 86.2 Ų · H-bond donors 1
XLogP
5.3
TPSA
86.2 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
29

SMILES C1CN(CCC12NC(=O)CS2)CCCN3C4=CC=CC=C4SC5=C3C=C(C=C5)Cl

Computed descriptors from PubChem (CID 65714), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.