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Chemical structure of PREP inhibitor-1

GC75252

PREP inhibitor-1

Also known as 1-[(2S)-2-[(2S)-2-(1H-imidazol-2-yl)pyrrolidine-1-carbonyl]pyrrolidin-1-yl]-4-phenylbutan-1-one

PREP inhibitor-1 (compound 27a) is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC50 < 1 nM)

ChemicalCAS2760543-16-4MW380.48FormulaC22H28N4O2
CAS number
2760543-16-4
Molecular weight
380.48
Formula
C22H28N4O2
InChIKey
REHZKZSJOGMLBE-OALUTQOASA-N
Catalogue number
GC75252
Brand
GLPBIO
Computed properties PubChem CID 163321208 · XLogP 2.2 · TPSA 69.3 Ų · H-bond donors 1
XLogP
2.2
TPSA
69.3 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
6
Heavy atoms
28

SMILES C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)CCCC3=CC=CC=C3)C4=NC=CN4

Computed descriptors from PubChem (CID 163321208), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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