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Chemical structure of 7-Deaza-2',3'-dideoxyguanosine

GC75242

7-Deaza-2',3'-dideoxyguanosine

Also known as 2-amino-7-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-3H-pyrrolo[2,3-d]pyrimidin-4-one

7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM

ChemicalCAS111869-49-9MW250.25FormulaC11H14N4O3
CAS number
111869-49-9
Molecular weight
250.25
Formula
C11H14N4O3
Solubility
DMSO: 125 mg/mL (499·50 mM; Need ultrasonic)
InChIKey
IRKZBFORRGBSAO-POYBYMJQSA-N
Catalogue number
GC75242
Brand
GLPBIO
Computed properties PubChem CID 135816720 · XLogP -1 · TPSA 102 Ų · H-bond donors 3
XLogP
-1
TPSA
102 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
18

SMILES C1C[C@@H](O[C@@H]1CO)N2C=CC3=C2N=C(NC3=O)N

Computed descriptors from PubChem (CID 135816720), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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