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Chemical structure of bpV(phen)

GC75202

bpV(phen)

Also known as potassium;oxovanadium;1,10-phenanthroline-1,10-diide;diperoxide

bpV(phen), a insulin-mimetic agent, is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor with IC50s of 38 nM, 343 nM and 920 nM for PTEN, PTP-β and PTP-1B, respectively· bpV(phen) inhibits proliferation of the protozoan parasite Leishmania in vitro· bpV(phen) strongly induces the secretion of a large number of chemokines and pro-inflammatory cytokines, and it activates a Th1-type pathway (IL-12, IFNγ)· bpV(phen) can also induce cell apoptosis, and has anti-angiogenic and anti-tumor activity

ChemicalCAS42494-73-5MW350.24FormulaC12H8KN2O5V
CAS number
42494-73-5
Molecular weight
350.24
Formula
C12H8KN2O5V
InChIKey
LXOJIFVIHKEULW-UHFFFAOYSA-N
Catalogue number
GC75202
Brand
GLPBIO
Computed properties PubChem CID 123131934 · TPSA 111 Ų · H-bond donors 0 · H-bond acceptors 7
TPSA
111 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
0
Heavy atoms
21

SMILES C1=C[N-]C2=C3C(=CC=C[N-]3)C=CC2=C1.[O-][O-].[O-][O-].O=[V].[K+]

Computed descriptors from PubChem (CID 123131934), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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