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Chemical structure of AG 538

GC75193

AG 538

Also known as (E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile

AG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM

ChemicalCAS133550-18-2MW297.26FormulaC16H11NO5
CAS number
133550-18-2
Molecular weight
297.26
Formula
C16H11NO5
Solubility
DMSO： 100 mg/mL (336·41 mM; Need ultrasonic)
InChIKey
CANOJKGQDCJDOX-VZUCSPMQSA-N
Catalogue number
GC75193
Brand
GLPBIO
Computed properties PubChem CID 5328760 · XLogP 2.2 · TPSA 122 Ų · H-bond donors 4
XLogP
2.2
TPSA
122 Ų
H-bond donors
4
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
22

SMILES C1=CC(=C(C=C1/C=C(\C#N)/C(=O)C2=CC(=C(C=C2)O)O)O)O

Computed descriptors from PubChem (CID 5328760), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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