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Chemical structure of Pomalidomide-C3-adavosertib

GC75169

Pomalidomide-C3-adavosertib

Also known as 2-(2,6-dioxopiperidin-3-yl)-4-[3-[4-[4-[[1-[6-(2-hydroxypropan-2-yl)-2-pyridinyl]-3-oxo-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-6-yl]amino]phenyl]piperazin-1-yl]propylamino]isoindole-1,3-dione

Pomalidomide-C3-adavosertib is a rapid and selective PROTAC Wee1 degrader (IC50=3·58 nM)

ChemicalCAS2414418-49-6MW799.88FormulaC42H45N11O6
CAS number
2414418-49-6
Molecular weight
799.88
Formula
C42H45N11O6
InChIKey
LZUDSNUROXNVPH-UHFFFAOYSA-N
Catalogue number
GC75169
Brand
GLPBIO
Computed properties PubChem CID 153555373 · XLogP 3.9 · TPSA 197 Ų · H-bond donors 4
XLogP
3.9
TPSA
197 Ų
H-bond donors
4
H-bond acceptors
14
Rotatable bonds
13
Heavy atoms
59

SMILES CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)CCCNC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)O

Computed descriptors from PubChem (CID 153555373), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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