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Chemical structure of MNK inhibitor 9

GC75058

MNK inhibitor 9

Also known as 2-[5-amino-6-[1-methyl-7-[(3S)-3-methylpiperazin-1-yl]benzimidazol-2-yl]pyrazin-2-yl]-N,N-dimethylpyridine-4-carboxamide

MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0·003 ?M and 0·003 ?M for MNK1 and MNK2 respectively

ChemicalCAS1889336-59-7MW471.56FormulaC25H29N9O
CAS number
1889336-59-7
Molecular weight
471.56
Formula
C25H29N9O
Solubility
DMSO： 6·67 mg/mL (14·14 mM; ultrasonic and warming and heat to 60°C)
InChIKey
FBTRDJIPJVBTHV-HNNXBMFYSA-N
Catalogue number
GC75058
Brand
GLPBIO
Computed properties PubChem CID 127047444 · XLogP 0.6 · TPSA 118 Ų · H-bond donors 2
XLogP
0.6
TPSA
118 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
35

SMILES C[C@H]1CN(CCN1)C2=CC=CC3=C2N(C(=N3)C4=NC(=CN=C4N)C5=NC=CC(=C5)C(=O)N(C)C)C

Computed descriptors from PubChem (CID 127047444), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.