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Chemical structure of Dolcanatide

GC74357

Dolcanatide

Also known as (2R)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2R)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid

Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist

ChemicalCAS1092457-65-2MW1681.89FormulaC65H104N18O26S4
CAS number
1092457-65-2
Molecular weight
1681.89
Formula
C65H104N18O26S4
Solubility
DMSO ： 100 mg/mL (59·46 mM; Need ultrasonic)
InChIKey
NSPHQWLKCGGCQR-HLHYUOOASA-N
Catalogue number
GC74357
Brand
GLPBIO
Computed properties PubChem CID 91826710 · XLogP -8.2 · TPSA 819 Ų · H-bond donors 23
XLogP
-8.2
TPSA
819 Ų
H-bond donors
23
H-bond acceptors
31
Rotatable bonds
28
Heavy atoms
113

SMILES C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](CC(=O)N)N

Computed descriptors from PubChem (CID 91826710), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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