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Chemical structure of VNPP433-3β

GC73896

VNPP433-3β

Also known as 1-[(3S,8R,9S,10R,13S,14S)-3-imidazol-1-yl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-17-yl]benzimidazole

VNPP433-3β is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2

ChemicalCAS1630820-51-7MW438.61FormulaC29H34N4
CAS number
1630820-51-7
Molecular weight
438.61
Formula
C29H34N4
Solubility
DMSO : 10 mg/mL (22·80 mM; ultrasonic and warming and heat to 60°C)
InChIKey
LKIKZGJOIUJYGD-IRGTZXILSA-N
Catalogue number
GC73896
Brand
GLPBIO
Computed properties PubChem CID 85468997 · XLogP 5.6 · TPSA 35.6 Ų · H-bond donors 0
XLogP
5.6
TPSA
35.6 Ų
H-bond donors
0
H-bond acceptors
2
Rotatable bonds
2
Heavy atoms
33

SMILES C[C@]12CC[C@@H](CC1=CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC=C4N5C=NC6=CC=CC=C65)C)N7C=CN=C7

Computed descriptors from PubChem (CID 85468997), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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