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Chemical structure of PRO-6E

GC73881

PRO-6E

Also known as 4-[8-[4-[4-[6-amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-3-pyridinyl]pyrazol-1-yl]piperidin-1-yl]-8-oxooctoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81·9% at 1 μM in MKN-45 cells

ChemicalCAS2353493-69-1MW848.75FormulaC42H44Cl2FN7O7
CAS number
2353493-69-1
Molecular weight
848.75
Formula
C42H44Cl2FN7O7
Solubility
DMSO ： ≥ 100 mg/mL (117·82 mM)
InChIKey
JSQFSAUVTNADLF-LZDHLTRGSA-N
Catalogue number
GC73881
Brand
GLPBIO
Computed properties PubChem CID 141762931 · XLogP 5.6 · TPSA 179 Ų · H-bond donors 2
XLogP
5.6
TPSA
179 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
15
Heavy atoms
59

SMILES C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCN(CC4)C(=O)CCCCCCCOC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)N

Computed descriptors from PubChem (CID 141762931), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.