Loading...
Chemical structure of JAB-2485

GC73744

JAB-2485

Also known as (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-[[5-fluoro-4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridinyl]methyl]-2-methylpiperidine-4-carboxylic acid

JAB-2485 is a potent and selective Aurora kinase A (AURKA) inhibitor, with an IC50 of 0·33 nM

ChemicalCAS2899209-55-1MW503.97FormulaC25H28ClF2N5O2
CAS number
2899209-55-1
Molecular weight
503.97
Formula
C25H28ClF2N5O2
Solubility
DMSO ： ≥ 100 mg/mL (198·42 mM)
InChIKey
CEONSWRDFKMFNM-PUAOIOHZSA-N
Catalogue number
GC73744
Brand
GLPBIO
Computed properties PubChem CID 163303906 · XLogP 2.8 · TPSA 94.1 Ų · H-bond donors 3
XLogP
2.8
TPSA
94.1 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
35

SMILES C[C@@H]1C[C@](CCN1CC2=C(C(=CC=C2)Cl)F)(CC3=NC(=C(C(=C3)C)F)NC4=NNC(=C4)C)C(=O)O

Computed descriptors from PubChem (CID 163303906), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.