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Chemical structure of Irpagratinib

GC73671

Irpagratinib

Also known as N-[(3S,4S)-3-[[6-(2,6-difluoro-3,5-dimethoxyphenyl)-8-(3-methoxy-3-methylazetidin-1-yl)pyrido[3,4-d]pyrimidin-2-yl]amino]oxan-4-yl]prop-2-enamide

Irpagratinib (ABSK011) is an orally active inhibitor of fibroblast growth factor receptor (FGFR) tyrosine kinase, targeting to FGFR4 (IC50＜10 nM)

ChemicalCAS2230974-62-4MW570.59FormulaC28H32F2N6O5
CAS number
2230974-62-4
Molecular weight
570.59
Formula
C28H32F2N6O5
Solubility
DMSO ： 100 mg/mL (175·26 mM; Need ultrasonic)
InChIKey
PGRHEHZIRYNZDV-FUHWJXTLSA-N
Catalogue number
GC73671
Brand
GLPBIO
Computed properties PubChem CID 135181440 · XLogP 2.9 · TPSA 120 Ų · H-bond donors 2
XLogP
2.9
TPSA
120 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
9
Heavy atoms
41

SMILES CC1(CN(C1)C2=C3C(=CC(=N2)C4=C(C(=CC(=C4F)OC)OC)F)C=NC(=N3)N[C@@H]5COCC[C@@H]5NC(=O)C=C)OC

Computed descriptors from PubChem (CID 135181440), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
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