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Chemical structure of SMD-3040

GC73660

SMD-3040

Also known as (2S,4R)-1-[(2S)-2-[[4-[[7-[4-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]pyrazol-1-yl]-2-azaspiro[3.5]nonan-2-yl]methyl]cyclohexanecarbonyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide

SMD-3040 is a potent and selective of SMARCA2 PROTAC degrader (DC50: 12 nM)

ChemicalCAS3033109-92-8MW943.21FormulaC52H66N10O5S
CAS number
3033109-92-8
Molecular weight
943.21
Formula
C52H66N10O5S
Solubility
DMSO ： ≥ 100 mg/mL (106·02 mM)
InChIKey
GMCWCUOAGNWNLO-LWMLYMNZSA-N
Catalogue number
GC73660
Brand
GLPBIO
Computed properties PubChem CID 168433318 · XLogP 5.8 · TPSA 233 Ų · H-bond donors 5
XLogP
5.8
TPSA
233 Ų
H-bond donors
5
H-bond acceptors
12
Rotatable bonds
13
Heavy atoms
68

SMILES CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4CCC(CC4)CN5CC6(C5)CCC(CC6)N7C=C(C=N7)C8=CC(=NN=C8N)C9=CC=CC=C9O)O

Computed descriptors from PubChem (CID 168433318), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.