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Chemical structure of DQP-997-74

GC73591

DQP-997-74

Also known as 4-[3-(4-chlorophenyl)-5-[4-(4-chlorophenyl)-2-oxo-1H-quinolin-3-yl]-3,4-dihydropyrazol-2-yl]-3,3-difluoro-4-oxobutanoic acid

DQP-997-74 (compound 2i) is a selective inhibitor of N-metl-d-aspartate receptor (NMDAR), specifically targeting GluN2C/D (IC50: 0·069 μM and 0·035 μM), with blood-brain barrier penetrability

ChemicalCAS2377187-09-0MW570.37FormulaC28H19Cl2F2N3O4
CAS number
2377187-09-0
Molecular weight
570.37
Formula
C28H19Cl2F2N3O4
Solubility
DMSO ： 100 mg/mL (175·32 mM; Need ultrasonic)
InChIKey
XJZPJUOPCITDPJ-UHFFFAOYSA-N
Catalogue number
GC73591
Brand
GLPBIO
Computed properties PubChem CID 136927371 · XLogP 4.9 · TPSA 99.1 Ų · H-bond donors 2
XLogP
4.9
TPSA
99.1 Ų
H-bond donors
2
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
39

SMILES C1C(N(N=C1C2=C(C3=CC=CC=C3NC2=O)C4=CC=C(C=C4)Cl)C(=O)C(CC(=O)O)(F)F)C5=CC=C(C=C5)Cl

Computed descriptors from PubChem (CID 136927371), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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