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Chemical structure of SWTX-143

GC73564

SWTX-143

Also known as N-[5-amino-1-[4-(trifluoromethyl)phenyl]-3,4-dihydro-2H-quinolin-3-yl]prop-2-enamide

SWTX-143 is an orally active YAP/TAZ-TEAD inhibitor that binds to the palmitoylation pocket of all four TEAD isoforms

ChemicalCAS2766575-48-6MW361.36FormulaC19H18F3N3O
CAS number
2766575-48-6
Molecular weight
361.36
Formula
C19H18F3N3O
Solubility
DMSO ： 125 mg/mL (345·92 mM; Need ultrasonic)
InChIKey
YZNSUDZUJLMKNI-UHFFFAOYSA-N
Catalogue number
GC73564
Brand
GLPBIO
Computed properties PubChem CID 163236085 · XLogP 3.8 · TPSA 58.4 Ų · H-bond donors 2
XLogP
3.8
TPSA
58.4 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
26

SMILES C=CC(=O)NC1CC2=C(C=CC=C2N(C1)C3=CC=C(C=C3)C(F)(F)F)N

Computed descriptors from PubChem (CID 163236085), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.