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Chemical structure of GGFG-amide-glycol-amide-Exatecan

GC73458

GGFG-amide-glycol-amide-Exatecan

Also known as 2-[[[2-[[(2S)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]ethyl N-[(10S,23S)-10-ethyl-18-fluoro-10-hydroxy-19-methyl-5,9-dioxo-8-oxa-4,15-diazahexacyclo[14.7.1.02,14.04,13.06,11.020,24]tetracosa-1,6(11),12,14,16,18,20(24)-heptaen-23-yl]carbamate

GGFG-amide-glycol-amide-Exatecan (Intermediate 2) is an Exatecan derivative and can be used in the synthesis of antibody-drug conjugates (ADCs)

ChemicalCAS2866301-18-8MW870.88FormulaC43H47FN8O11
CAS number
2866301-18-8
Molecular weight
870.88
Formula
C43H47FN8O11
Solubility
DMSO : 100 mg/mL (114·83 mM; Need ultrasonic)
InChIKey
MEANSBFOEJBQOJ-BMANKKTJSA-N
Catalogue number
GC73458
Brand
GLPBIO
Computed properties PubChem CID 171361076 · XLogP -0.5 · TPSA 270 Ų · H-bond donors 7
XLogP
-0.5
TPSA
270 Ų
H-bond donors
7
H-bond acceptors
14
Rotatable bonds
17
Heavy atoms
63

SMILES CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)NC(=O)OCCOCNC(=O)CNC(=O)[C@H](CC7=CC=CC=C7)NC(=O)CNC(=O)CN)O

Computed descriptors from PubChem (CID 171361076), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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